825470062 825470062
top of page

Evolving Science

Resources on What Science is Being Conducted to Help Diagnosis or Improve Health after mTBI/Concussion.


Mitochondria are the energy factories that exits within almost every cell and they are the key to Photobiomodulation.  Mitochondria have a substance called cytochrome oxidase that can absorb red and near-infrared light and convert the energy into a form of biological energy called adenosine triphosphate (or "ATP"). 

et al https://vielight.com/photobiomodulation/



Mechanisms of Brain Photobiomodulation

There are several mechanisms associated with promoting physiological change through photobiomodulation therapy (PBMT). The wavelengths primarily used with PBM is within the near-infrared range of the electromagnetic spectrum with a sufficient power density. When hypoxic/impaired cells are irradiated with low-level NIR photons, there is increased mitochondrial adenosine triphosphate (ATP) production within their mitochondria.1, 2 Another change is the release of nitric oxide from the hypoxic/impaired cells. Neurons are cells that contain mitochondria and nitric oxide.

In hypoxic neuronal cells, cytochrome-C oxidase (CCO), a membrane-bound protein that serves as the end-point electron acceptor in the cell respiration electron transport chain, becomes inhibited by non-covalent binding of nitric oxide. When exposed to NIR photons, the CCO releases nitric oxide, which then diffuses outs of the cell – increasing local blood flow and vasodilation.3, 4

Following initial exposure to the NIR photons, there is a brief burst of reactive oxygen species (ROS) in the neuron cell, and this activates a number of signaling pathways. The ROS leads to activation of redox-sensitive genes, and related transcription factors including NF-κβ.5, 6 The PBMT stimulates gene expression for cellular proliferation, migration, and the production of anti-inflammatory cytokines and growth factors.7 

et al https://vielight.com/brain-photobiomodulation/

bottom of page